Adie’s pupil is a neurological condition of unknown
origin with an unusual, asymmetric presentation known
as anisocoria, an inequality in the size of the pupils of
the eyes. It is believed to be a result of damage to the
nerve innervating a muscle of the eye known as the ciliary
body. Alternately, the problem may be located at the
ciliary ganglion, a kind of nerve junction structure from
which the nerve to the ciliary body runs. Accommodation,
or the adjustment of the eye for distance, is affected,
as well as pupillary dilation and contraction, the ability
of the eye’s iris to open or close in response to ambient
light. Adie’s pupil primarily affects women from 20
to 40 years of age. It is considered to be a benign condition
with no known cure. When Deep Tendon Reflexes
(DTRs) of the legs—knee and ankle jerks—are also affected,
accompanied by symptoms including localized,
discreet areas of the skin that do not sweat, postural hypotension
(low blood pressure related to sudden standing
or rising), and unsteady heart rhythms, the condition is
referred to as Adie’s syndrome.






